A large study carried out at Changhai Hospital in Shanghai, involving over 500 chinese hospital patients, has demonstrated the efficacy of probiotics in helping to reduce the side effects of antibiotics, specifically antibiotic-associated diarrhoea (AAD) and Clostridium difficile associated diarrhoea (CDAD). The aim of the study was to determine the effect of a four strain probiotic combination on the incidence of AAD and CDAD and severity of gastrointestinal symptoms in adult hospital patients requiring antibiotic therapy.

A specific 4 strain blend of Lactobacillus and Bifidobacterium bacteria, a combination found in our For every day EXTRA Strength product, was trialled in the triple-blind, dose-response study. The probiotic blend was administered daily to the hospital patients, for a period of up to 7 days after antibiotic use.

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The 4 strains of bacteria shown to reduce symptoms of AAD in the study are found in For every day EXTRA Strength

The study, recently published in Vaccine, reported a significant reduction in a number of gastrointestinal symptoms such as fever, bloating and abdominal discomfort. A higher dosage of the probiotic blend was also shown to reduce the number of liquid stools and duration of diarrhoea. Also, interestingly, incidences of fever, abdominal pain, and bloating were lower with an increasing probiotic dose. This is an area that will however be explored further, as the study states "it should not be interpreted that a higher dose is always superior for any probiotic strain (combination)". It is also worth mentioning that it is possible to have too many strains in a probiotic supplement - you may like to read more about this here.

Antibiotics may cause side effects such as diarrhoea and abdominal discomfort

The results are of particular interest due to the large scale of the study. As the researchers state, "the present study is one of the largest studies with probiotics and AAD and is the only dose-response study with probiotics on AAD in adults".

This latest research further demonstrates the potential benefits of our best-selling For every day EXTRA Strength product. You may like to read more about our clinical trials, or for more information about For every day EXTRA Strength please click here.

Reference: Ouwehand AC, Donglian C, Weijan X, Stewart M, Ni J, Stewart T & Miller LE. Probiotics reduce symptoms of antibiotic use in a hospital setting: A randomized dose response study. Vaccine. 2014 2014 Jan 16;32(4):458-63. doi: 10.1016/j.vaccine.2013.11.053. Epub 2013 Nov 26.

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