Probiotics Learning Lab Impartially created by the experts at OptiBac

Live cultures can be taken in almost any circumstances and by all ages. More information can be found in our frequently asked questions. However, there are a very small number of circumstances when we recommend that they are NOT taken without a discussion with your doctor first as they may be contraindicated with either a medical condition or another drug.

What is a contraindication?

A contraindication is a specific situation (or medical condition) in which a drug, procedure, or even surgery should not be used because it may be harmful to the patient.

What medical conditions may be contraindicated with live cultures?

Live cultures are not recommended for those with serious medical conditions eg. those who are severely immunosuppressed, have pancreatitis, are in the ICU, have melaena, have a central venous catheter, infants with short bowel syndrome, or to patients with open wounds following major surgery; unless under a doctor's care. Furthermore, pregnant or breastfeeding women should consult their doctor before taking certain live cultures.

However, these medical circumstances have only been highlighted as there is limited research on how live cultures react with them. It is therefore recommended that live cultures are not taken in these circumstances unless with the advice of a doctor. We also suggest you contact providers directly for guidance on their products.

Are there any drugs or supplements with which live cultures may be contraindicated?

There are no known contraindications with medical drugs or supplements, however there are some considerations when taking live cultures with certain medications or supplements:
  • If taking probiotic bacteria alongside antibiotics you would need to take these 1-2 hours away from your medication, unless taking live cultures supplements which are specifically formulated for taking with antibiotics. For more information on this please see our FAQ on taking antibiotics with live cultures.This may also be a consideration when taking bacterial live cultures alongside other natural supplements which have an anti-microbial action.
  • If you are taking anti-fungal medication or natural supplements with anti-fungal properties, then again you would need to take probiotic yeasts at a different time of day.
  • If you are taking immunosuppressant medication, then you should speak to your doctor before taking probiotics. See this FAQ for more information: 'I'm severely immunosuppressed: why can't I take live cultures?'
You may like further information on the following:
Healthcare practitioners see: Can I become addicted to live cultures?


This FAQ has been answered by Joanna Scott-Lutyens, BA (hons), DipION, Nutritional Therapist.