Bifidobacterium lactis Bi-07
Bifidobacterium lactis Bi-07 is a gram-positive, anaerobic, rod-shaped bacterium which can be found in the large intestines of most mammals. This strain was recently reclassified as Bifidobacterium animalis subsp. lactis Bi-07, but for ease it tends to be known as Bifidobacterium lactis Bi-07 (Masco et al., 2004). It may sometimes be seen named as Bifidobacterium lactis ATCC SD5220.
Bifidobacterium lactis Bi-07 for Immunity
The ability of gut bacteria to modulate the immune system has been the focus of much microbiome research. Evidence suggests that probiotic bacteria may have the ability to affect certain immune responses: they may improve the response to oral vaccination; reduce the risk of certain types of infection or shorten its duration, or reduce the risk of or alleviate the symptoms of allergy and other immune-based conditions. Bifidobacterium lactis Bi-07 is one of the bacterial strains that has been used extensively in research studies to determine the role of probiotics in immune function, and the resulting evidence suggests that it may be one of the best strains for this purpose.
Bifidobacterium lactis Bi-07 was tested for its ability to stimulate a specific immunity reaction in response to vaccination. Human volunteers were orally vaccinated using cholera vaccine as a vaccination model. Over a 21 day period they were then given either a daily placebo (maltodextrin) or a daily supplement of Bifidobacterium lactis Bi-07. Blood samples were collected on day 0, 21 and 28, to test levels of IgG (immunoglobulin G) antibodies. It was found that those in the probiotic group displayed faster and higher IgG induction than in the control group, which suggested that there had been stimulation of a specific immune response by Bifidobacterium lactis Bi-07 (Paineau et al. 2008).
In another double-blind, placebo-controlled study, 326 eligible children (3–5 years of age) were randomly given either a placebo, a probiotic containing Lactobacillus acidophilus NCFM®, or a probiotic containing Lactobacillus acidophilus NCFM® in combination with Bifidobacterium lactis Bi-07 over a six month period.
The results indicated that, in comparison to the placebo group, both single and combination probiotics reduced incidences of fever by 53.0% and 72.7%, incidences of coughing by 41.4% and 62.1% and rhinorrhoea (runny nose) incidence by 28.2% and 58.8% respectively Fever, coughing, and rhinorrhoea duration was decreased significantly, relative to placebo, by 32% using the single strain and 48% in the group given the strain combination, compared to the placebo group. The need for antibiotics was also reduced, relative to placebo, as was absence from school due to illness, compared with subjects receiving placebo treatment (Leyer et al., 2009).
A double-blind, randomised and controlled trial conducted by Lehtinen et al. (2014) looked at daily supplementation with Bifidobacterium lactis Bi-07 on 37 elderly subjects. The authors found beneficial effects on the immune responses of the participants, noted as an increase in phagocytic activity of both monocytes and granulocytes, one of the immunological mechanisms by which the body helps prevent itself from infections and illness.
In another recent double-blind, randomised, placebo-controlled Australian study, 465 participants who exercised regularly were investigated to see if probiotics would help to support their immune function, as significant exercise can place a burden on the immune system and lead to increased incidence of coughs and colds. The subjects were split into three groups: the subjects in the first group took a supplement containing only Bifidobacterium lactis Bi-07, those in the second group took a combination of L. acidophilus NCFM® & B. lactis Bi-07, and those in the third group were given a placebo.
Over the 5 months of the trial it was found that the first group had a 27% decreased risk of contracting an upper respiratory infection. Those in the second group also had a decrease in their risk of infection, but it was not as significant as that seen in the first group, indicating that it was the Bifidobacterium lactis Bi-07 which offered the greatest potential benefit for immune support; however, both probiotic groups experienced improved immunity compared to the placebo group - see below (West et al., 2014).
Further Relevant Studies:
Foligne et al (2007), Maneerat et al (2013), Wagner et al. (1997), Wagner et al. (1998), Wagner et al. (2000).
Bifidobacterium lactis Bi-07 for Stabilisation of Gut Microbiota During and Post Antibiotic Intervention
As documented throughout this database, antibiotic drugs are known to affect the composition of the gut microbiota, sometimes adversely, and research is being carried out to determine whether probiotics can help to minimise this disturbance. Bifidobacterium lactis Bi-07 has been tested for this purpose in combination with other strains of bacteria.
One such study used 51 randomised healthy subjects, who were administered with amoxicillin/clavulanate antibiotics over a period of 48 days. Subjects were divided into two groups, in which the members were given either a probiotic supplement or a placebo. Prior to antibiotic therapy, the subjects gave three faecal samples to establish their microbiota patterns when healthy, then four faecal samples were taken post antibiotic therapy for comparison. The results showed that those subjects who took the probiotic showed less disturbance in their faecal microbiota, and had a more rapid return to their pre-antibiotic microbial state (Engelbrektson, 2006).
A further study attempted to determine whether symptoms of diarrhoea responded more positively to higher or lower doses of probiotic bacteria. As part of the study, Bifidobacterium lactis Bi-07 was given to subjects in combination with three other strains of bacteria including B. lactis Bl-04, L. acidophilus NCFM®, and L. paracasei Lpc-37. The 510 participants were all suffering from diarrhoea symptoms, either antibiotic-associated diarrhoea or diarrhoea caused by Clostridium difficile infection. They were divided into three groups: subjects in the first group were given a placebo, and two treatment groups were each given the probiotic supplement of differing strengths. One group received a dose of 17 billion CFU and the other group received a dose of just over 4 billion CFU; results indicated that the higher dose of the probiotic supplement was more effective than the lower dose in alleviating diarrhoea symptoms, including the duration and incidence in a hospital setting (Ouwehand et al., 2014).
Bifidobacterium lactis Bi-07 for Diarrhoea in Children
Diarrhoea is a common and unpleasant digestive symptom for all age groups and as such, as you will see from many of the other strain pages in this database, this symptom has become a key area of focus in probiotic research. It can be a particularly serious problem in children, who may become quickly dehydrated and debilitated when suffering from loose stools for prolonged periods of time. The potential for probiotics to reduce the incidence of childhood diarrhoea was evaluated in a double-blind, placebo-controlled, randomised clinical trial. A total of 243 children aged 12-36 months were recruited for the purposes of the study, and divided into two groups. One group received a placebo, and the treatment group received a probiotic supplement containing Bifidobacterium lactis Bi-07 as part of a three-strain combination (also including a Lactobacillus reuteri strain (not specified) and Lactobacillus acidophilus NCFM®). During the 14-week intervention period, a statistically significant reduction in the incidence and frequency of diarrhoea episodes was recorded in the probiotic group compared to the placebo group (Ruiz-Palacios, G. F. et al., 1999).
Bifidobacterium lactis Bi-07 for Bloating Symptoms
Bloating and distension are very common digestive symptoms which occur due to a build-up of gases in the abdominal area. This can be caused by indigestion, an overgrowth of harmful bacteria or yeasts in the intestines, or as a side effect of slow stool transit and constipation.
A placebo controlled, double blind clinical trial attempted to determine whether a probiotic supplement containing Bifidobacterium lactis Bi-07 in combination with Lactobacillus acidophilus NCFM® would alleviate bloating symptoms in the test group. A total of 57 patients with IBS (without constipation), diarrhoea and functional bloating were enrolled and randomly given a placebo or probiotic for 8 weeks. It was found that the supplementation of these probiotics significantly improved distention and bloating in the treatment group (Ringel et al., 2008).
Bifidobacterium lactis Bi-07 for Post-Colonoscopy Pain
Up to 20% of patients may experience abdominal pain post colonoscopy; this is believed to be due to alterations in the gut flora, so probiotics have been considered to be one of the best potentially helpful natural solutions.
In a recent trial, 320 randomised subjects awaiting colonoscopy were divided into two groups. Following their procedures, one group was given a probiotic containing Lactobacillus acidophilus NCFM® and Bifidobacterium lactis Bi-07, and the other group was given a placebo capsule. Results showed a significant reduction in the duration of pain experienced by patients in the probiotic treatment group compared with placebo (D’Souza et al., 2015).
Bifidobacterium lactis Bi-07 for Atopic Dermatitis
Atopic dermatitis (AD) is an increasingly common chronic inflammatory skin disease which is a cause of considerable distress, particularly in afflicted children. Solutions for prevention and treatment of this condition are the focus of a growing area of research, and as the integrity of the intestinal mucosal barrier is thought to be implicated with atopic dermatitis (AD), a role for probiotics has been considered.
In a double-blind, randomised placebo-controlled intervention using 50 children with AD, the children were given either a placebo, or a probiotic supplement containing either Lactobacillus acidophilus NCFM® or Bifidobacterium lactis Bi-07. Clinical and immunological changes were evaluated after ingestion of the probiotic strains, and a measurable reduction in the severity of AD was observed in the Bi-07 group (Gobel et al., 2010).
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