For daily immunity - Scientific Research
‘For daily immunity’ contains 5 billion CFUs of Lactobacillus paracasei CASEI 431®, a single strain of bacteria which has been tested on thousands of people in over 20 clinical trials. Research has shown this strain stands alone to support the immune system, specifically helping to improve immune responses and reduce duration of cold & flu symptoms. By combining it with 100% of your Nutrient Reference Value (NRV) of Vitamin C, the supplement offers additional immune support.
Many people do not realise that 70% of our immune cells are found in the gut, and research strongly indicates the importance of a healthy gut microbiome to optimal immune function. The study of live cultures also reveals that the actions of bacteria in the body are strain specific. ‘For daily immunity’ is a unique live cultures supplement to help support your immune function.
Understanding clinical research on immunity:
A vaccine study is a research model whereby the body is exposed to a fragment of infection, as a way of observing the body’s immune response to it.
Vaccine studies are considered the best study design for investigating the effects a control (e.g. probiotic or placebo) has on immune function. This is because it is generally quite difficult to test an immune reaction in someone who is not ill and testing people who are already ill does not accurately represent the general population. Vaccine studies allow us to see how a ‘healthy’ person’s immune system reacts to an infection and how the probiotic influences its response.
Clinical trials on Lactobacillus paracasei CASEI 431®
L. paracasei CASEI 431® reduces duration of illness
In the first, large gold standard clinical trial to investigate the effect of a probiotic strain on the immune response to vaccination in healthy adults, 1104 healthy adults were split into two groups:
Participants took either 1 billion CFU/day of L. paracasei CASEI 431® or placebo for 3 weeks before and after receiving the flu vaccine.
L. paracasei CASEI 431® significantly sped up recovery from flu-like illness by 3 days, compared to the placebo.
- The L. paracasei CASEI 431® group used fewer antibiotics than the placebo group.
Jespersen, et al (2015) Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study. Am.J.Clin.Nutr.; 101(6):1188-1196
L. paracasei CASEI 431® improves immune function
In a gold standard flu vaccine challenge study, 211 healthy participants took either a probiotic (1 billion L. paracasei CASEI 431®) or a placebo. Each group received their supplement 2 weeks prior to their vaccine and continued to take it for 4 weeks afterwards.
- In the probiotic group levels of IgG increased by 37%
IgG is an antigen which controls infection by binding onto pathogens and activating immune responses which eliminates them.
- Significantly increased secretory IgA in saliva compared to placebo.
IgA is important for the immune function of mucous membranes.
Rizzardini, et al. (2012) Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study. Br.J.Nutr.;107:876-84
L. paracasei CASEI 431® helps to improve immune & inflammatory response to infection
A study compared the effect of two different probiotics on immune responses to the polio vaccine.
64 healthy adults were split into 3 groups. They were given either 10 Billion CFU/day of B bifidum LGG®, L. paracasei CASEI 431® or a placebo for 1 week prior to being administered with the polio vaccine and then for the following 4 weeks.
- The graph indicates the significant increase in IgM in the L. paracasei CASEI 431® group.
IgM is the first and largest antibody to respond to an infection and initiates the other immune responses.
- There was a 2-6 fold increase in neutralising antibodies in the L. paracasei CASEI 431® vs. placebo group.
Neutralising antibodies help to reduce side effects of the immune response.
- Overall, significantly improved immune responses were seen post-vaccination in the L. paracasei CASEI 431® group.
De Vrese, et al. (2005) Probiotic bacteria stimulate virus-specific neutralizing antibodies following a booster polio vaccination. Eur.J.Nutr.;44:406-413
Vitamin C reduces the frequency of the common cold - 2006
A study published in the European Journal of Clinical Nutrition (2006) conducted a double blind 5 year randomised controlled trial. A daily supplement of Vitamin C was given to participants. It was found that this significantly reduces the frequency of catching a cold.
- Sasazuki, S., Sasaki, S., Tsubono, Y., et al (2006) Effect of vitamin C on common cold: randomized controlled trial. Epidemiology and Prevention pision, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan. European Journal of Clinical Nutrition, 2006 Jan; 60 (1): 9-17.
Valsecchi, et al. (2014) Evaluation of the effects of a probiotic supplementation with respect to placebo on intestinal microflora and secretory IgA production, during antibiotic therapy, in children affected by recurrent airway infections and skin symptoms. J.Biol.Regul.Homeost.Agents;28(1):117-124
Agustina, et al. (2013) Probiotics Lactobacillus reuteri DSM 17938 and Lactobacillus casei CRL 431 Modestly Increase Growth, but Not Iron and Zinc Status, among Indonesian Children Aged 1-6 Years. J.Nutr.;143(7):1184-1193
Tulk, et al. (2013) Daily consumption of a synbiotic yogurt decreases energy intake but does not improve gastrointestinal transit time: a double-blind, randomized, crossover study in healthy adults. Nutr.J.;12(1):87-.
Agustina, et al. (2012) Randomized trial of probiotics and calcium on diarrhea and respiratory tract infections in Indonesian children. Pediatrics;129(5):e1155-64
Malpeli, et al. (2012) Randomised, double-blind and placebo-controlled study of the effect of a synbiotic dairy product on orocecal transit time in healthy adult women Nutr.Hosp.;27(4):1314-1319
Nova, et al. (2011) Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J.Med.Food;14:79-85
Perez, et al. (2010) Effect of probiotic supplementation on immunoglobulins, isoagglutinins and antibody response in children of low socio-economic status. Eur.J.Nutr;49:173-179
van Baarlen, et al. (2010) Microbes and Health Sackler Colloquium: Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways. Proc.Natl.Acad.Sci.U.S.A.;Epub ahead of print:.
Vlieger, et al. (2009) Tolerance and safety of Lactobacillus paracasei ssp. paracasei in combination with Bifidobacterium animalis ssp. lactis in a prebiotic-containing infant formula: a randomised controlled trial. Br.J.Nutr.;102:869-875
Hol, et al. (2008) The acquisition of tolerance toward cow's milk through probiotic supplementation: a randomized, controlled trial. J.Allergy Clin.Immunol.;121:1448-1454
Christensen, et al. (2006) Immunomodulating potential of supplementation with probiotics: a dose-response study in healthy young adults. FEMS Immunol.Med.Microbiol.;47:380-390
Larsen, et al. (2006) Dose-response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults. Eur.J.Clin.Nutr.;60(11):12841293
Gaon, et al. (2003) Effect of Lactobacillus strains and Saccharomyces boulardii on persistent diarrhea in children. Medicina;63:293-298
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