For daily immunity - Scientific Research
Recent research on probiotics and immunity
Below are clinical trials looking generally at probiotics and immunity.
Combination of Probiotics & prebiotics improve anti-oxidative activity - January 2008 - A blend of Lactobacillus and Bifidobacterium probiotics with the prebiotic oligofructose was linked to a reduction in the oxidation of LDL, associated with hardening of the arteries. This EU and MicroFunction Project concluded that the overall antioxidant activity of the participants taking synbiotic supplements was higher than the antioxidant activity of placebo subjects.
Source: Proceedings of the Nutrition Society. 2007, Volume 66, Page 101A (2007)Effects of a synbiotic on biomarkers of oxidative stress and faecal microbiota in healthy adults: results of a cross-over double-blind placebo-controlled trial.
Probiotics support athletes with infections and colds- July 2014 - The latest research published in the Journal of Science and Medicine in Sport in July 2014, performed a randomized controlled trial on thirty elite rugby players in New Zealand. The players were allocated in random order to either receive probiotics or a placebo for four weeks each. It was found that the athletes had about 40% fewer colds and gastrointestinal infections when they took a probiotic compared to when they took a placebo.
- Haywood, Brylee A. et al. (2012) Probiotic supplementation reduces the duration and incidence of infections but not severity in elite rugby union players. Journal of Science and Medicine in Sport , Volume 17 , Issue 4 , 356 – 360
Probiotics reduce duration of respiratory illness and days off sick - July 2014 - In a Meta-analysis published in the British Journal of Nutrition in July 2014 twenty randomised control trials looking at the effect of probiotics and immunity were considered. It was concluded that ‘the average duration of respiratory illness episodes, the number of days of illness per person and the number of days absent from day care/work/school are significantly reduced with probiotic treatment compared with placebo’.
- Sarah King et al (2014) Effectiveness of probiotics on the duration of illness in healthy children and adults who develop common acute respiratory infectious conditions: a systematic review and meta-analysis.British Journal of Nutrition. July 2014; 112(1): 41–54.
Antioxidants & Natural Plant Extracts for Immunity
Below is a small selection of the research on the natural plant extracts (antioxidants) found in OptiBac Probiotics 'For daily immunity'.
Grape Seed Extract can destroy leukaemia cells - January 2009 - Scientists at the University of Kentucky found that within 24 hours of exposure to Grape Seed Extract, 76% of leukaemia cells died through apoptosis, a natural process of self-destruction. This research could potentially provide new areas of treatment for leukaemia, a disease that affects over 24,000 people each year. Grape Seed Extract, previously shown to reduce the size of breast tumours in rats and skin tumours in mice, contains numerous antioxidants including resveratrol – a component known for its anti-cancerous properties. Head researcher, Professor Xianglin Shi added, “What everyone seeks is an agent that has an effect on cancer cells but leaves normal cells alone, and this shows that grapeseed extract fits into this category.”
- Ning Gao et al. (2009) Induction of Apoptosis in Human Leukemia Cells by Grape Seed Extract Occurs via Activation of c-Jun NH2-Terminal Kinase.Clinical Cancer Research January 1, 2009 15:140-149;
Green Tea good for the heart – July 2008 - A small Greek study found that habitual consumption of green tea could ameliorate the function of the endothelial cells (the cells lining the walls of blood vessels), therefore boosting cardiovascular health. The study indicated the possible role of green tea polyphenols, which have previously been linked to protection against some cancers and Alzheimer’s disease.
- Alexopoulos et al. The acute effect of green tea consumption on endothelial function in healthy inpiduals.European Journal of Cardiovascular Prevention & Rehabilitation, 2008; 15 (3)
Pine bark has anti-inflammatory and analgesic activities - 2012. A study published in the Advances in Pharmacologcial Sciences (2012), tested a pine native to the Himalaya. Pinus roxburghii Sarg. (Pinaceae) where it is traditionally and extensively used in number of herbal preparation for curing inflammatory disorders, this study was undertaken to assess analgesic and anti-inflammatory activities of its bark extract. Dried and crushed leaves of this pine were defatted with petroleum ether and then extracted with alcohol. This was then subjected to evaluation of analgesic and anti-inflammatory activities in experimental animal models. It was found that the alcoholic bark extract of demonstrated significant analgesic and anti-inflammatory activities in the tested models.
- Dhirender Kaushik, Ajay Kumar, Pawan Kaushik, A. C. Rana (2012) Analgesic and Anti-Inflammatory Activity of Pinus roxburghii Sarg.Advances in Pharmacological Sciences. 2012; 2012: 245431.
Vitamin C reduces the frequency of the common cold - 2006. A study published in the European Journal of Clinical Nutrition (2006) conducted a double blind 5 year randomized controlled trial. Daily supplementation of vitamin C was given to participants. It was found that this significantly reduces the frequency of catching a cold.
- Sasazuki, S., Sasaki, S., Tsubono, Y., et al (2006) Effect of vitamin C on common cold: randomized controlled trial. Epidemiology and Prevention pision, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan. European Journal of Clinical Nutrition, 2006 Jan; 60 (1): 9-17.
Clinical Research on probiotics and immunity
Drisko, J. A. et al. (2003) Probiotics in Health Maintenance and Disease Prevention. Alternative Medicine Review; Vol. 8 (2) pp. 143 - 156
Hill, M. J. (1997) Intestinal flora and endogenous vitamin synthesis. European Journal of Cancer Prevention; Vol. 6 Suppl.1 pp. S43 – 5
Famularo, G. et al (2005) Probiotic lactobacilli: an innovative tool to correct the malabsorption syndrome of vegetarians? Medical Hypotheses; Vol. 65 (6) pp.1132 – 5
Hebuterne, X. (2003) Gut changes attributed to ageing: effects on intestinal microflora. Current Opinion in Clinical Nutrition and Metabolic Care; Vol. 6 (1) pp. 49 – 54.
Hughes, D. A. (1999) Effects of dietary antioxidants on the immune function of middle-aged adults. Proceedings of Nutrition Society; Vol. 58 (1) pp. 79 - 84
Forchielli, M. L. & Walker, W. A. (2005) The role of gut-associated lymphoid tissues and mucosal defence. British Journal of Nutrition; Vol. 93 Suppl. 1 pp. S41 – 8
Fasano, A. & Shea-Donohue, T. (2005) Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nature Clinical Practice Gastroenterology & Hepatology; Vol. 2 (9) pp.416 – 422.