For every day is a combination of 6 different live cultures, including two Lactobacillus strains, three Bifidobacterium strains and a Lactococcus strain, as well as FOS fibres. These strains have all been proven to survive stomach acidity to reach the gut alive. What's more, the two Lactobacillus strains (L. acidophilus Rosell-52 andL. rhamnosus Rosell-11) are some of the most researched live culture strains in the world, providing a formula well suited to help support daily digestive healthy and wellbeing.

Clinical research on the strains in OptiBac Probiotics 'For every day'

L. acidophilus Rosell-52 and B. longum Rosell-175 - June 2017 - A small pilot study of 10 participants, with diagnosed depressive disorders, aimed to evaluate the effects of L. acidophilus Rosell-52 & B. longum Rosell-175 on depression symptoms, such as low mood, anhedonia (inability to feel pleasure) and sleep disturbance. Participants were assessed using the Montgomery-Asberg depression rating scale to monitor mood symptoms, and sleep was monitored by observing brain activity, heart rate, and eye movement during the night. Participants supplemented with probiotics showed significant improvements in their symptoms, including improved sleep quality, mood score, and the ability to feel pleasure.
Source: Wallace, C. et al (2017) Findings presented at 13th World Congress of Biological Psychiatry. Poster P-05-015, presented June 19, 2017.

'For every day' probiotic strains show potential for Stress - October 2010 - Lactobacillus acidophilus Rosell-52 & Bifidobacterium longum Rosell-175, two of the probiotics in 'For every day' (For daily wellbeing), were demonstrated to be beneficial in an innovative new trial linking gut health and stress levels. Published in the British Journal of Nutrition, this clinical trial found that the two probiotic strains are able to cause beneficial psychological effects in humans. 'These results provide further evidence that gut microflora play a role in stress, anxiety and depression' the French scientist reported. Volunteers were administered with either the two 'For every day' (For daily wellbeing) probiotic strains, or a placebo, every day for 30 days, and then tested for stress and anxiety levels. The probiotic group showed significant improvement in psychological distress, depression, anger-hostility and anxiety.

Source: Mr Messaoudi et al., Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British Journal of Nutrition, 10.1017/S0007114510004319

Lactobacillus acidophilus Rosell-52 has been shown to have a favourable impact on sleep in the elderly – 2009 - The study included 29 healthy subjects aged 60-81 years old who were given a Lactobacillus helveticus (this is in fact the same, but re-categorised as Lactobacillus acidophilus Rosell-52) fermented milk drink for 3 weeks. The same were then given a ‘wash out period’ and then given a placebo drink. Sleep quality was measured by means of actigraphy and a sleep questionnaire. It was found that the probiotic drink significantly improved the quality of sleep as well as number of waking hours, whereas the placebo didn't.

Yamamura S, Morishima H, Kumano-go T, et al. (2009) The effect of Lactobacillus helveticus fermented milk on sleep and health perception in elderly subjects. Eur J Nutr 63, 100–105

Lifelong prebiotic supplementation could extend lifespan by over 30% - April 2008 - An animal study at the Université Henri Poincare Nancy I administered rats with the prebiotics inulin and oligofructose (FOS). Results demonstrated increased survival rates in rats given the prebiotics, and also lower body weight and lower cholesterol when compared to rats in the control group. Within the male rats groups, at 18 months old all animals on prebiotics were still alive, compared to 76% of the rats not on prebiotics.

Source: British Journal of Nutrition Published online ahead of print, 11 Apr 2008, doi: 10.1017/S0007114508975607, "Effects of lifelong intervention with an oligofructose-enriched inulin in rats on general health and lifespan" Authors: P. Rozan, A. Nejdi, S. Hidalgo, J.-F. Bisson, D. Desor, M. Messaoudi

Probiotics ease stress-related gut problems - January 2008 – Leading probiotic firm, Lallemand, led a double-blind study which randomly assigned either probiotics or placebos to 75 volunteers from 18 to 60 years old. Participants who received probiotics Lactobacillus acidophilus Rosell-52 and Bifidobacterium longum Rosell-175 reported considerable reduction in abdominal pain and nausea or vomiting compared to participants in the control group. Authors of the study at the Institut Rosell commented that this probiotic supplement could act on the intestinal microflora, the epithelial barrier, and the immune system in order to improve gastrointestinal problems induced by stress.

Source: Nutrition Research (Elsevier) Volume 28, Issue 1, January 2008, Pages 1-5 "Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: a double-blind, placebo-controlled, randomized trial" Authors: L. Diop, S. Guillou, H. Durand

Clinical Research on probiotics and wellbeing

Below are summaries of clinical trials on either the same, or similar families (genus) or species of bacteria as those found in 'For every day'; but please note that not all of these clinical trials have used the exact same strains as found in 'For every day'.

Synbiotics (both probiotics and prebiotics) reduce risk of colon cancer - February 2007 - A large study sponsored by the EU found that a mix of both probiotics and prebiotics largely modified the composition of the colonic bacterial ecosystem, and could in this way diminish the amount of cancer-promoting bacteria. The number of Clostridium perfringens, a bacterial strain thought to convert dietary substances to carcinogenic compounds, decreased notably in participants given the synbiotic product. Lead author Joseph Rafter stated that use of synbiotics may represent a fine means of “chemoprevention of colon cancer in humans”.

Source: American Journal of Clinical Nutrition Volume 85, Pages 488-496 "Dietary synbiotics reduce cancer risk factors in polypectomised and colon cancer patients"

Probiotics restore bowel flora and improve liver enzymes in alcohol-induced liver injury – December 2008 - A study on 66 Russians with alcoholic psychosis and 24 healthy controls found the alcoholic patients to have significantly less Bifidobacteria and Lactobacilli in their systems than participants without alcoholic psychosis. Giving Bifidobacterium bifidum and Lactobacillus plantarum to the alcoholic patients restored their bowel microbiota, and improved their liver health significantly more than standard therapy on its own.

For an abstract of the study, see http://www.alcoholjournal.org/article/S0741-8329(08)00301-7/abstract

Role of prebiotics in reducing artery hardening & boosting heart health – January 2007 - Researchers at the Human Nutrition Research Centre in Auvergne found that mice given long-chain inulin or an oligofructose-enriched inulin showed significantly reduced levels of triacylglycerol and 30% less atherosclerotic plaque. Atherosclerosis (hardening of the arteries) is a major risk factor in cardiovascular disease, which causes up to 50% of deaths in Europe.

Source: M-H Rault-Nania et al., British Journal of Nutrition, Volume 96, Number 5, Pages 840-844

Williams E, et al (2008) Clinical trial: a multi strain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. Aliment Pharmacol Ther. September 10 2008

Kocian, J. (1996). Further Possibilities in the Treatment of Lactose Intolerance: Lactobacilli. Prakticky Lekar (General Practitioner). Vol. 74. pp. 212 – 214

Hill, M. J. (1997) Intestinal flora and endogenous vitamin synthesis. European Journal of Cancer Prevention; Vol. 6 Suppl. 1 pp. S43 – 5

Guarner, F. & Malagelada, J. R. (2003) Gut flora in health and disease. Lancet; Vol. 8 pp. 512 – 9

Gibson, G.R. & Wang, X. (1994) Regulatory Effects of Bifidobacteria on the growth of other colonic bacteria. The Journal of Applied Bacteriology. Oct;77(4):412-20.

Drisko, J. A, et al. (2003) Probiotics in health maintenance and disease prevention. Alternative Medicine Review; Vol. 8 (2) pp.143 - 55.

Kimoto, H. et al (2004) New Lactococcus strain with immunomodulatory activity: enhancement of Th1-type immune response. Microbiology and Immunology; Vol. 48 (2) pp.75 – 82

Kumar et al. (2005) Beneficial effects of probiotics and prebiotics on human health; Pharmazie Vol. 60 (3) pp.163 – 71

Saavedra, J. & Tschernia, A. (2002) Human studies with probiotics and prebiotics: clinical implications. British Journal of Nutrition, Volume 87, Supplement s2, 1 May 2002, pp. 241-246(6)

Gibson, G. R. et al (1995) Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology. Apr;108(4):975-82.

Diop, L. et al. (2007) Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: a double-blind, placebo-controlled, randomised trial. Nutrition Research 28.

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