One week flat is an expert formulation of 4 live cultures strains, including Lactobacillus acidophilus Rosell-52, Lactobacillus casei Rosell-215, Lactococcus lactis Rosell-1058, Bifidobacterium bifidum Rosell-71, and FOS fibres. The live cultures found in 'One week flat' have been tested and proven to survive stomach acidity and to reach the intestinal tract alive. What's more, in-vitro studies have shown that the strains found in 'One week flat' may help to support gut health in those with abdominal bloating, in various ways. This includes producing specific enzymes that help with the digestion, competing with methane producing bacteria (which can cause bloating), as well as producing lactic acid to decrease pH in the gut so bad bacteria cannot flourish.

Clinical Research on Probiotics, Prebiotics and Abdominal Bloating

The research referred to below refers to clinical trials carried out on the families, species, and in some but not all cases, the specific strains of bacteria found in OptiBac Probiotics 'One week flat'.

We have also listed some research on the active ingredient Fructooligosaccharides (FOS) - as found in 'One week flat' - and bloating.

Additionally, the image below demonstrates some of the understood mechanisms of actions of the probiotic strains in 'One week flat', as demonstrated by in-vitro tests.

Lactobacillus acidophilus & body weight and leptin expression in rats - February 2008 - This study by Sousa et al at the University of Georgia, Athens, reported that rats administered with the probiotic Lactobacillus acidophilus showed weight loss in comparison to rats that were not given the probiotics. Injecting acidophilus supernatant into the Central Nervous Systems of the rats led to greater expression of leptin, a protein hormone that decreases the appetite and quickens the metabolism.

To read the entire study, see

Probiotics ease stress-related gut problems - January 2008 - Leading probiotic company, Lallemand led a double-blind study that randomly assigned either probiotics or placebos to 75 volunteers between the ages of 18 and 60. Participants given the probiotics Lactobacillus acidophilus Rosell-52 and Bifidobacterium longum Rosell-175 reported a significant reduction in abdominal pain and nausea or vomiting compared to participants given placebos. Authors of the study at Lallemand commented that this probiotic supplement could work on the intestinal microbiota, the epithelial barrier, and the immune system in order to improve problems in the gut which were induced by stress. These two specific strains are both found in 'One week flat'.

Source: Nutrition Research (Elsevier) Volume 28, Issue 1, January 2008, Pages 1-5 "Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: a double-blind, placebo-controlled, randomized trial" Authors: L. Diop, S. Guillou, H. Durand

Prebiotics help to avoid weight gain in adolescents - October 2007 - A study published in the Journal of Pediatrics and conducted at the Baylor College of Medicine stated that especially during puberty, an imbalance between energy intake and expenditure can cause weight gain and possible obesity. The study, involving 97 healthy adolescents, gave participants either inulin/oligofructose (FOS) or a placebo for the period of a year. Results showed less increase in BMI amongst the group given prebiotics, with considerably lower body weight and body fat mass in these participants compared to the controls.

Source – “Effect of Prebiotic Supplementation and Calcium intake on Body Mass Index.” Journal of Pediatrics, September 2007, Volume 151, Pages 293-298.

Marteau, P. & Boutron-Ruault, M. C. (2002) Nutritional Advantages of Probiotics and Prebiotics. British Journal of Nutrition. Vol. 87 Suppl. 2 pp. S153 – S157

Paineau, D. (2007) Regular consumption of short-chain fructooligosaccharides improves digestive comfort with minor functional bowel disorders. Br. J. Nutr. Aug 13:1-8 [Epub ahead of print]

Colecchia, A. (2006) Effect of a symbiotic preparation on the clinical manifestations of irritable bowel syndrome, constipation-variant. Minerva Gastroenterol. Dietol. 2006. 52:349-358

Tokunaga, T. (1993) Effects of fructooligosachharides (FOS) intake on the intestinal microflora and defecation in healthy volunteers. Bifidus. (6) 143-150.

Houghton, L. A. & Whorwell, P. J. (2005) Towards a better understanding of abdominal bloating and distension in functional gastrointestinal disorders. Neurogastroenterology & Motility. Vol. 17 pp. 500 – 511

Zar, S, et al. (2002) Review Article: bloating in functional bowel disorders. Alimentary Pharmacology and Therapeutics. Vol. 16 pp. 1867 - 1876

Kumar, D. et al. (2005) Beneficial effects of probiotics and prebiotics on human health; Pharmazie Vol. 60 (3) pp.163 – 171

Gibson, G. R. et al (1995) Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology. Apr;108(4):975-82.

Wallace, T.D. et al. (2003) Interactions of lactic acid bacteria with human intestinal epithelial cells: effects on cytokine production. Journal of Food Protection, 66, 3; 446-472.