Bifidobacterium infantis 35624

Heavily studied for IBS and its symptoms
Well researched for inflammatory conditions
Shown to help with mood and behavioural issues

As with many other strains in this database, this bacterial strain has been researched to assess its potential benefits for the relief of Irritable Bowel Syndrome (IBS) and the associated symptoms. The following studies suggest that it may do so because it has an anti-inflammatory effect in the body. It is important to note that this strain is also known as Bifantis®.

Bifidobacterium infantis 35624 for Irritable Bowel Syndrome (IBS)

In a randomised, multiple-dosage, parallel, placebo-controlled, double-blind clinical trial, 75 male and female participants with various presentations of IBS (either constipation, diarrhoea or alternating symptoms) were given either a Lactobacillus salivarius strain or the Bifidobacterium infantis 35624 strain for a period of 8 weeks. Symptoms of IBS were assessed daily. Blood sampling for the measurement of cytokines IL-10 or IL-12 took place at the beginning and end of the study, and these were also compared against the cytokine levels of healthy volunteers. For the individual symptom scores, B. infantis 35624 was associated with a significant reduction in pain/discomfort, bloating/distention, and difficulty passing a bowel movement. Another important finding was that, also following B. infantis 35624 use, cytokine levels in the IBS subjects were similar to the levels in the healthy volunteers, while the levels were not significantly changed in either of the other treatment groups (O’Mahony et al., 2005).

You are in the B. infantis section of the database.


Another large scale multicentre, randomised, multiple-dosage, parallel, placebo-controlled, double-blind clinical trial on women was conducted in order to determine the best dosage of Bifidobacterium infantis 35624 for IBS. The trial used 362 female subjects, all aged between18 to 65 years and diagnosed with IBS. The women were randomly split into groups and given one of three different doses of B. infantis 35624: 1 million, 100 million, or ten billion. B. infantis at the dosage of a hundred million had statistically lower symptom scores at week 4 of the treatment phase for abdominal pain/discomfort, bloating/distention, sense of incomplete evacuation, passage of gas, straining, and bowel habit satisfaction than those receiving placebo - see right (Whorwell et al., 2006).

Whorwell 2006 - B. infantis 35624 reduced symptoms of IBS compared to placebo

Further relevant studies: Bairead et al (2005), Brenner (2009a), Brenner et al (2009b), Chang et al (2005), Charbonneau et al., (2005a), Charbonneau et al., (2005b), Charbonneau et al., (2005c), Charbonneau et al., (2005d), Chen K-S et al (2005), Mayer (2008), O’Mahony et al., (2005), Quigley et al (2005a), Quigley et al (2005b).

Also relevant: see all strains in the database which have been researched for IBS.

Bifidobacterium infantis 35624 for Inflammatory Conditions - Ulcerative Colitis, Chronic Fatigue Syndrome and Psoriasis

In a study authored by Konieczna (2012), cytokine secretion and T cell expression were monitored in individuals who were given Bifidobacterium infantis 35624. It was found that B. infantis administration in humans promotes immuno-regulatory responses, suggesting that this microbe may have therapeutic utility in patients with inflammatory disease. These findings link nutrition, gut microbiota and the induction of tolerance within the gastrointestinal mucosa.

Bifidobacterium infantis 35624 was also found to modulate inflammatory processes beyond the gut. Groeger et al (2013) assessed the impact of oral administration of B. infantis 35624, for 6‒8 weeks on inflammatory biomarker and plasma cytokine levels in patients with ulcerative colitis, chronic fatigue syndrome and psoriasis in three separate randomised, double-blind, placebo-controlled interventions. In addition to this, the effect of B. infantis 35624 on immunological biomarkers in healthy subjects was assessed. This strain of bacteria resulted in a reduced plasma CRP levels in all three inflammatory disorders. Compared with the placebo results, additionally plasma TNF-α was reduced in chronic fatigue syndrome and psoriasis, while IL-6 was reduced in ulcerative colitis and chronic fatigue syndrome. These results show the ability of this microbe to reduce pro-inflammatory markers both in the gut and systemically.

Further relevant studies: Gad et al., (2011), Johnson et al., (2011), Konieczna et al., (2013), Scully et al (2013) Symonds et al., (2012), van der Kleij et al., (2008), O’Mahony et al., (2005), Sheil et al (2007), Shanahan et al (2006), Sommerfield et al (2003), Symonds et al (2007), Wall et al (2010), von Wright et al (2002).

Also relevant: see all strains in the database researched for IBD and mental health.

Bifidobacterium infantis 35624 and Mood

This strain has been used in rat studies conducted by Desbonnet et al., (2008) (2010), to assess the effects of probiotics on behaviour and mood. Results suggested that probiotic treatment resulted in normalisation of the immune response, reversal of behavioural issues and reduction in depressive symptoms.

Also relevant: see all strains in the database which have been researched for mental health.

Bifidobacterium infantis 35624 for Inflammation

In the same O’Mahony et al (2005) trial that is described in the IBS section above, it was found that the ratio of anti-inflammatory to pro-inflammatory cytokines in the gut was normalised. This suggests an immune-modulating role for this microorganism, in this disorder.

Further relevant studies: Davies et al (2009), McCarthy et al (2003), O’Callaghan et al (2002), O’Callaghan et al (2003), O’Callaghan et al (2004), O’Mahony et al (2008), O’Mahony et al (2005), O’Mahony et al (2006), Sheil et al.(2006a), Sheil et al., (2006b) Shilling et al., (2005), Sibartie et al., (2009).

Bifidobacterium infantis 35624 for Other Digestive Symptoms and Infections

A pilot study by Frech et al (2011) indicated a role for probiotics to support systemic sclerosis (SSc) patients with systemic sclerosis-associated re-flux and distention/ bloating symptoms. Improvements in symptoms and total gastrointestinal tract (GIT) disease scales were noted.

Some protection against Salmonella infection and its damaging effects were noted in a variety of murine studies - O’Mahony et al., (2002), O’Mahony et al., (2004), O'Hara et al, (2006), Sommerfield et al., (2005).

This strain is currently not available in the OptiBac Probiotics range.



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Bibliography

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Konieczna P. et al. (2012) Bifidobacterium infantis 35624 administration induces Foxp3 T Regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells’, Gut. 61(3):354-66.
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Last updated - 07th July, 2017

 


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